Misa lost her entire family in a bombing raid on Tokyo during World War II. She became very depressed and had given up on life, settling down to die when a little boy came up to her and asked her to try a piece of meat. The meat turned out to be the flesh of a mermaid, and Misa was granted eternal life. She named the boy Masato and the two lived happily together for many years. Masato never told her that they were immortals so she became distressed when he never aged. One night she strangled him in frustation but he came back to life.
The Meaning Behind the Name
Because her name is giving only in the anime and not the manga, it is difficult to break down her name without the kanji.
Rei Sakuma took over for the TV series. She is known to Takahashi fans as the voice of Shampoo in Ranma ½. Some of her other roles are Morrigan in Darkstalkers, Konoha Edajima in Please Teacher!, Jiji in Kiki's Delivery Service and Fatima Clotho in Five Star Stories.
Janyse Jaud provided the voice for Misa in the OVA of Mermaid's Scar. She is a Takahashi mainstay, providing the voice for Akemi Roppongi in Maison Ikkoku, Hinako Ninomiya in Ranma ½, and Kagura in Inuyasha.
Gina Grad played Misa in the TV series. She doesn't have many credits to her name, but her roles include Swan in Ergo Proxy and Michiko Hirota in Texhnolyze.